Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
作者： Jian-Fang Ning , Monica Stanciu , Melissa R. Humphrey , Joshua Gorham , Hiroko Wakimoto
DOI: 10.1038/S41467-019-10993-5
关键词: Poly ADP ribose polymerase 、 Blockade 、 Plasma protein binding 、 Cancer research 、 Gene knockdown 、 Homologous recombination 、 PARP inhibitor 、 Chemistry 、 Neoplasm 、 Antigen
摘要: … for PARPi sensitivity in GSCs, we used doxycycline (Dox)-inducible short hairpin RNA (… Fisher Scientific) and cloned into inducible lentivector Tet-pLKO-puro (Addgene) according to the …
nature.com
harvard.edu
sci-hub.se 参考文章(69)
Christian Rolfo, Helen Swaisland, Karin Leunen, Annemie Rutten, Patricia Soetekouw, Sarah Slater, Henk M. W. Verheul, Anitra Fielding, Karen So, Wendy Bannister, Emma Dean, Effect of Food on the Pharmacokinetics of Olaparib after Oral Dosing of the Capsule Formulation in Patients with Advanced Solid Tumors Advances in Therapy. ,vol. 32, pp. 510- 522 ,(2015) , 10.1007/S12325-015-0214-4
Justin D. Lathia, Stephen C. Mack, Erin E. Mulkearns-Hubert, Claudia L.L. Valentim, Jeremy N. Rich, Cancer stem cells in glioblastoma Genes & Development. ,vol. 29, pp. 1203- 1217 ,(2015) , 10.1101/GAD.261982.115
Joan Seoane, Hong-Van Le, Joan Massagué, Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage Nature. ,vol. 419, pp. 729- 734 ,(2002) , 10.1038/NATURE01119
Adam R. Cole, PCTK proteins: the forgotten brain kinases? Neurosignals. ,vol. 17, pp. 288- 297 ,(2009) , 10.1159/000231895
Ajay Pandita, Kenneth D. Aldape, Gelareh Zadeh, Abhijit Guha, C. David James, Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes, Chromosomes and Cancer. ,vol. 39, pp. 29- 36 ,(2004) , 10.1002/GCC.10300
Ilirjana Bajrami, Jessica R. Frankum, Asha Konde, Rowan E. Miller, Farah L. Rehman, Rachel Brough, James Campbell, David Sims, Rumana Rafiq, Sean Hooper, Lina Chen, Iwanka Kozarewa, Ioannis Assiotis, Kerry Fenwick, Rachael Natrajan, Christopher J. Lord, Alan Ashworth, Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer Research. ,vol. 74, pp. 287- 297 ,(2014) , 10.1158/0008-5472.CAN-13-2541
Monika Podhorecka, Andrzej Skladanowski, Przemyslaw Bozko, H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy Journal of Nucleic Acids. ,vol. 2010, pp. 944- 945 ,(2010) , 10.4061/2010/920161
Neil Johnson, Yu-Chen Li, Zandra E Walton, Katherine A Cheng, Danan Li, Scott J Rodig, Lisa A Moreau, Christine Unitt, Roderick T Bronson, Huw D Thomas, David R Newell, Alan D D'Andrea, Nicola J Curtin, Kwok-Kin Wong, Geoffrey I Shapiro, Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition Nature Medicine. ,vol. 17, pp. 875- 882 ,(2011) , 10.1038/NM.2377
Susanne Walz, Francesca Lorenzin, Jennifer Morton, Katrin E. Wiese, Björn von Eyss, Steffi Herold, Lukas Rycak, Hélène Dumay-Odelot, Saadia Karim, Marek Bartkuhn, Frederik Roels, Torsten Wüstefeld, Matthias Fischer, Martin Teichmann, Lars Zender, Chia-Lin Wei, Owen Sansom, Elmar Wolf, Martin Eilers, Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles Nature. ,vol. 511, pp. 483- 487 ,(2014) , 10.1038/NATURE13473
Jeongwu Lee, Svetlana Kotliarova, Yuri Kotliarov, Aiguo Li, Qin Su, Nicholas M. Donin, Sandra Pastorino, Benjamin W. Purow, Neil Christopher, Wei Zhang, John K. Park, Howard A. Fine, Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. ,vol. 9, pp. 391- 403 ,(2006) , 10.1016/J.CCR.2006.03.030