Efficient synthesis and anti-enteroviral activity of 9-arylpurines
作者： Leire Aguado , María-Dolores Canela , Hendrik Jan Thibaut , Eva-María Priego , María-José Camarasa
DOI: 10.1016/J.EJMECH.2012.01.022
关键词: Toxicity 、 Substituent 、 Chemistry 、 Vero cell 、 Biochemistry 、 Aryl 、 Virus 、 Stereochemistry 、 Alkyl 、 Enterovirus 、 Purine metabolism
摘要: Abstract To further explore the anti-enteroviral activity of 9-aryl-6-chloropurines, three different series compounds with a dialkylamino, (alkyl)amido, or oxazolidinone substituent at aryl ring have been synthesized, in most cases aid microwave-assisted synthesis. The resulting efficiently inhibit Coxsackie virus type B3 (CVB3) replication EC 50 values varying from 3 to 15 μM, and no significant toxicity Vero cells. potent also selectively other enteroviruses including B4 Echo 11. cross-resistance studies performed 9-aryl-6-chloropurines indicate that they all belong same pharmacological family differ CVB3 drugs such as enviroxime.
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