T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes.

摘要: Insulin-dependent diabetes mellitus (IDDM) results from the selective destruction of pancreatic β cells by a T cell-mediated autoimmune process. Insulin and proinsulin are only known cell-specific autoantigens. Using short-term cultures freshly isolated peripheral blood mononuclear cells, we evaluated T-cell responses to insulin in IDDM patients individuals at risk for IDDM. A proliferative response was observed 2 26 recent-onset subjects 12 long-standing associated with insulin. In contrast, 5 13 islet cell autoantibody-positive first-degree relatives showed alone, 3 1 both proinsulin. Overall, 9 ICA-positive responded either or We an inverse relationship between antiinsulin antibodies but not patients. Our data indicate that is major antigen and, further, illustrate difference immune exogenous