Validation and Quality Control of an ICP‐MS Method for the Quantification and Discrimination of Trace Metals and Application in Paper Analysis: An Overview

摘要: Questioned documents analysis includes: handwriting comparison, of the ink and printer used in production documents, physical chemical characterization cellulosic substrate (paper) documents. In many situations life, for financial, social, personal concerns, we depend on different Therefore, over time, various analytical methods have been developed order to determine their authenticity, source, age or differentiate papers. this study a quantitative method determination eight trace level elements (Al, Ba, Fe, Mg, Mn, Pb, Sr, Zn) from document paper samples using inductively coupled plasma-mass spectrometry (ICP-MS) was validated applied. The evaluation performance parameters (applicability, fitness purpose, linearity, working range, limit detection quantification, sensitivity, accuracy, precision) accomplished. An overview validation are presented discussed detail.