The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
作者： Amir Fayyazuddin , Mahira A Zaheer , P. Robin Hiesinger , Hugo J Bellen
DOI: 10.1371/JOURNAL.PBIO.0040063
关键词: Central nervous system 、 Biology 、 Motor neuron 、 Endocrinology 、 Cholinergic synapse 、 Receptor 、 Neuroscience 、 Escape response 、 Nicotinic acetylcholine receptor 、 Interneuron 、 Acetylcholine 、 Internal medicine
摘要: Acetylcholine is the major excitatory neurotransmitter in central nervous system of insects. Mutant analysis Dα7 nicotinic acetylcholine receptor (nAChR) ofDrosophila shows that it required for giant fiber-mediated escape behavior. The protein enriched dendrites fiber, and electrophysiological fiber circuit showed sensory input to disrupted, as transmission at an identified cholinergic synapse between peripherally synapsing interneuron dorsal lateral muscle motor neuron. Moreover, we found thatgfA1, a mutation screen defects more than twenty years ago, allele ofDα7. Therefore, combination behavioral, electrophysiological, anatomical, genetic data indicate essential role nAChR inDrosophila.
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