Towards Unifying Protein Evolution Theory

摘要: There are many proposed models for protein domain evolution. The main contention [1], however, is between divergent [2] and convergent [3] of Divergent evolution proposes that there was an ancestor to all domains we see today consequently historically related each other. Convergent claims chance largely responsible the appearance new kinds domains. explains prevalence certain types structures by stating those more favorable often recycled different functions. distinction neither abstract nor purely academic. If primary model domains, then it possible reconstruct lineages follow structural change, predict contextual functional ranges occur due well-defined evolutionary pressures. However, if driving force behind functions, in principle should be no discernable structure–function relationship. An important step understanding quantification dominant scenario(s) as theoretical background derivation correlation. Here, describe recent advances this direction.