Histopathologycal findings in the ovaries and uterus of albino female rats promoted by co-administration of synthetic steroids and nicotine

摘要: The use of anabolic androgenic steroids is often associated with the other substances, licit or not, such as nicotine present in tobacco. study investigated for first time effects co-administration synthetic and on ovarian uterine tissue fertility adult female rats. Animals were submitted to treatment groups (n=16/group): nandrolone decanoate (ND; 7.5mg/kg BW/week); testosterone mixture (T; (N; 2.0mg/kg BW/day), ND/N, T/N ND/T/N. control group received saline solution daily. injections administered subcutaneously 30 consecutive days. Results demonstrated that all androgenized rats exhibited estral acyclicity there was suppression reproductive capacity due notable histological changes. Treatments promoted decrease (p<0.05) weight. Uterine weight increased T groups, comparison group. ND co-administered not intense follicular degeneration, formation cysts ovaries. High levels circulating androgens ND/T/N induced presence sex cord-stromal tumors Sertoli cell pattern. Androgenized females presented endometrial changes characterized by papilliferous pleated luminal epithelium, oedematous hemorrhagic stroma gland cysts. In conclusion, three drugs atypical morphological pattern ovaries uterus