An interpenetrating polymer network hydrogel with biodegradability through controlling self-assembling peptide behavior with hydrolyzable cross-linking networks

摘要: Abstract Hydrogels are used as cell culture scaffolds for tissue engineering and regeneration. These hydrogel designs inevitably complicated because favorable should have stiffness to sustain alignment of the cells mimic the structure extracellular matrix (ECM) in targeted tissue. However, incorporation biodegradability, which is an essential property practical applications, into complex hydrogels not easily attained. Herein, we established a new concept constructing biodegradable with interpenetrating polymer network (IPN) structure, composed covalent cross-linked peptide self-assembling networks, solve this dilemma selecting between complicated facile biodegradability. Assuming that diffusion self-assembled peptides out IPN would be facilitated by disappearance designed chitosan poly(ethylene glycol)-block-poly( dl -lactide)-block-poly(ethylene glycol) networks hydrolysis properties RADA16 networks. This showed overall degradation, based on poly( -lactide) domain, was more effective scaffold culturing chondrocytes form articular cartilage tissues compared without likely owing promotion ECM deposition. results verified our strategy complicated, but biodegradable, structure.