The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance?

作者: August Heidland , Przemyslaw Rutkowski , Udo Bahner , André Klassen

DOI:

关键词: Cancer developmentSingle processMedicineInflammationHuman PathologySine qua nonCellular pathologyEpistemologySocial medicineFunctio laesaPhysiology

摘要: At the beginning of 19th century, medicine was based largely on speculative and philosophical concepts. The greatest merit Rudolf Virchow without doubt a way thinking natural science. In place empirical chaos represented by doctrines humors crasis, he created new paradigm cellular pathology. field inflammation, critically analyzed meaning four key symptoms inflammation (redness, swelling, heat pain) postulated that cannot be as single process but rather constitutes various inflammatory processes. addition introduced functio laesa , denoting restricted function inflamed tissues. pathogenesis highlighted importance stimulus. irritatio is starting point conditio sine qua non . Through his pathohistological investigations in experimental animals humans, widely accepted central cause atherosclerosis, until end has been confirmed recent decades. It who first coined term endarteriitis deformans Likewise, also to hypothesize link between microinflammation subsequent cancer development. This hypothesis recently corroborated numerous studies may have therapeutic consequences. contributed nearly all aspects human pathology championed social medicine.

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