Genetic Association between Eotaxin Genes and Asthma and Its Relationship to Birth Season in Korean Children
作者： In-Sung Ahn , Se-Eun Bae , Jeong-Hee Kim , Byong-Kwan Son , Hyeon-S. Son
关键词: Bronchoconstriction 、 Phenotype 、 Haplotype 、 Genetic association 、 Inflammation 、 Immunology 、 Gene 、 Asthma 、 Eotaxin 、 Biology
摘要: Abstract Asthma is a chronic disease associated with airway constriction due to inflammation caused by eosinophils, mast cells, and T lymphocytes, leading serious illness in children. The eotaxin gene family has been shown play an important role the patho-genesis of asthma. We hypothesized that distinctive variations among four seasons Korea may affect expression polymorphisms, especially examined possible effects birth sea-son (spring, March-May; summer, June-August; fall, September-November; winter, December-February) on phenotype asthma All SNP data sets eotaxin-2 eotaxin-3 genes were col-lected from 78 patients 101 controls. Here, we investigated season ex-pression Korean Using HAPLOTYPE procedure HTR method SAS/Genetics, showed children born spring summer show significant haplotypes both eo-taxin-2 genes. Thus, polymorphisms vary season.Keywords: asthma, haplotype, eotaxin, children,
koreascience.or.kr参考文章(28)
Marco Baggiolini, Clemens A. Dahinden, CC chemokines in allergic inflammation. Immunology Today. ,vol. 15, pp. 127- 133 ,(1994) , 10.1016/0167-5699(94)90156-2
R ALAM, Chemokines in allergic inflammation. The Journal of Allergy and Clinical Immunology. ,vol. 99, pp. 273- 277 ,(1997) , 10.1016/S0091-6749(97)70042-3
Motoji Kitaura, Noriko Suzuki, Toshio Imai, Shin Takagi, Ryuji Suzuki, Toshiharu Nakajima, Koichi Hirai, Hisayuki Nomiyama, Osamu Yoshie, Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3 * Journal of Biological Chemistry. ,vol. 274, pp. 27975- 27980 ,(1999) , 10.1074/JBC.274.39.27975
Juan R González, Lluís Armengol, Xavier Solé, Elisabet Guinó, Josep M Mercader, Xavier Estivill, Víctor Moreno, SNPassoc: an R package to perform whole genome association studies Bioinformatics. ,vol. 23, pp. 654- 655 ,(2007) , 10.1093/BIOINFORMATICS/BTM025
Soo-Cheon Chae, Yong-Chul Lee, Young-Ran Park, Jung-Sup Shin, Ju-Hee Song, Gyung-Jae Oh, Seong-Tshool Hong, Hyun-Ock Pae, Byung-Min Choi, Hun-Taeg Chung, Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. Biochemical and Biophysical Research Communications. ,vol. 320, pp. 131- 137 ,(2004) , 10.1016/J.BBRC.2004.05.136
Jan Vijg, Nathalie J. van Orsouw, Two-dimensional gene scanning: exploring human genetic variability. Electrophoresis. ,vol. 20, pp. 1239- 1249 ,(1999) , 10.1002/(SICI)1522-2683(19990101)20:6<1239::AID-ELPS1239>3.0.CO;2-T
P J Jose, D A Griffiths-Johnson, P D Collins, D T Walsh, R Moqbel, N F Totty, O Truong, J J Hsuan, T J Williams, Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. Journal of Experimental Medicine. ,vol. 179, pp. 881- 887 ,(1994) , 10.1084/JEM.179.3.881
M Uguccioni, C R Mackay, B Ochensberger, P Loetscher, S Rhis, G J LaRosa, P Rao, P D Ponath, M Baggiolini, C A Dahinden, High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Journal of Clinical Investigation. ,vol. 100, pp. 1137- 1143 ,(1997) , 10.1172/JCI119624
L Nilsson, B Bjorksten, G Hattevig, B Kjellman, N Sigurs, N-I M Kjellman, Season of birth as predictor of atopic manifestations Archives of Disease in Childhood. ,vol. 76, pp. 341- 344 ,(1997) , 10.1136/ADC.76.4.341
HIDETOSHI NAKAMURA, SCOTT T. WEISS, ELLIOT ISRAEL, ANDREW D. LUSTER, JEFFREY M. DRAZEN, CRAIG M. LILLY, Eotaxin and impaired lung function in asthma. American Journal of Respiratory and Critical Care Medicine. ,vol. 160, pp. 1952- 1956 ,(1999) , 10.1164/AJRCCM.160.6.9811089