A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study.

摘要: Objective: A proprietary natural fiber complex (Litramine IQP G-002AS) derived from Opuntia ficus-indica, and standardized on lipophilic activity, was previously shown in preclinical human studies to reduce dietary fat absorption through gastrointestinal (GI) binding. Here, we investigated the efficacy safety of G-002AS body weight reduction. Design Methods: One hundred twenty-five overweight obese adults participated study. Subjects were advised physical received nutritional counseling, including hypocaloric diet plans (30% energy 500 kcal deficit/day). After a 2-week placebo run-in phase, subjects randomized receive either 3 g/day (IQ) or placebo. The primary endpoint change baseline; secondary endpoints included additional obesity measures parameters. Results: One twenty-three completed 12-week treatment phase (intention-to-treat (ITT) population: 30 male 93 female; mean BMI: 29.6 ± 2.8 kg/m2 age: 45.4 11.3 years). baseline 3.8 1.8 kg IQ vs. 1.4 2.6 (P < 0.001). More lost at least 5% their initial compared = 0.027). Compared with placebo, also showed significantly greater reduction BMI, composition, waist circumference. well tolerated no adverse reactions reported. Conclusions: These results suggest that Litramine is effective promoting loss.