Progress towards development of a photolytic artificial lung

摘要: Abstract While most chronic diseases are on the decline, medical pulmonary disease is increase. The unrelenting nature of lung has long energized community to seek technologies replicate capacity lungs exchange oxygen for carbon dioxide. such artificial work by delivering blood through a system hollow fibers or tubes, our approach employs photolytic energy generate from water already present in blood, thus eliminating need gas delivery. To this end, progress development (PAL) reported. device provides photolytically driven electrochemistry oxygenation maintenance breathing air confined spaces. based catalyzed photoactivity transition metal oxide as titanium dioxide (TiO 2 ). Photoactive anatase TiO films have been developed use lung. PAL capable facilitating thereby bypassing alveolar–capillary interfaces. will eventually be used ex-vitro and in-vitro devices. direct process, using UV laser radiation, converts liquid phase (dissolved oxygen), with commensurate reduction test cell consisted an indium tin coating, coating (∼2 μm thick), MnO overcoat deposited fused silica reactive magnetron sputtering. Blood flowed over coated side occurred at interface. Three hundred fifty-four nanometers radiation was incident silica/indium (ITO) side. Electron–hole pairs were generated layer which redox reaction blood. also catalyst dissolve Oxyhemoglobin increased much 90% process. maximum rate generation 1.08 ml O /(m  min), projecting alveolar surface area 75 m . We conclude that it feasible oxygenate hemoglobin contained whole derived blood's own content.