Synthesis of new derivatives of copper complexes of Josiphos family ligands for applications in asymmetric catalysis
作者： R. Oost , J. Rong , A. J. Minnaard , S. R. Harutyunyan
DOI: 10.1039/C4CY00180J
关键词: Catalysis 、 Reagent 、 Combinatorial chemistry 、 Chemistry 、 Ligand 、 Hydrosilylation 、 Enantioselective synthesis 、 Steric effects 、 Copper 、 Organic chemistry 、 Moiety
摘要: A series of new copper complexes containing chiral ferrocenyl diphosphine ligands the Josiphos family have been prepared. These studied in catalytic asymmetric 1,2-addition Grignard reagents to enones and aromatic ketones. Variation electronic steric properties ligand resulted a positive effect regio- enantioselectivity α-H-substituted using which tert-butyl substituents were introduced diarylphosphine moiety. The also successfully applied conjugate addition enoates. No increase was observed linear reagents, compared that commercially available rev-Josiphos.
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