Randomized trial of bilateral oophorectomy versus tamoxifen in premenopausal women with metastatic breast cancer
作者： J N Ingle , J E Krook , S J Green , T P Kubista , L K Everson
关键词: Hormonal therapy 、 Oophorectomy 、 Time to progression 、 Medicine 、 Bilateral oophorectomy 、 Metastatic breast cancer 、 Internal medicine 、 Oncology 、 Randomized controlled trial 、 Tamoxifen 、 Initial treatment
摘要: A randomized clinical trial was performed to compare the efficacy of bilateral oophorectomy with that tamoxifen at a dose 10 mg twice daily in premenopausal women metastatic breast cancer, and examine each as crossover treatment. Initial treatment responses were seen ten 27 patients (37%) treated seven 26 (27%) tamoxifen. The difference not statistically significant. Crossover five 15 (33%) oophorectomy, including three prior nonresponders; two 18 (11%) Time progression distributions significantly different during initial treatment, no significant differences survival noted. Thus, there overall disadvantage use opposed hormonal therapy, failure respond did preclude response subsequent oophorecto...
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