Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T > C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters.
作者： Rakesh Naidu Rakesh Naidu , YC Har , NAM Taib , None
DOI: 10.3109/00365513.2011.590223
关键词: Genotyping 、 Allele 、 Heterozygote advantage 、 Genotype 、 Molecular biology 、 Internal medicine 、 Malignancy 、 Gastroenterology 、 Breast cancer 、 Statistical significance 、 Logistic regression 、 Medicine
摘要: AbstractBackground. The purpose of this study was to investigate the association between peptidyl-propyl-cis/trans isomerase 1 (PIN1) −842(G > C) and −667(T polymorphic variants breast cancer risk among Malaysian ethnic groups namely Malays, Chinese Indians, as well clinico-pathological characteristics patients. Patients Methods. polymerase chain reaction-restriction fragment length polymorphism used genotype 387 patients 252 normal healthy women who had no history any malignancy. Results. distribution genotypes alleles frequencies cases individuals showed lack statistical significance Malays (p 0.05), 0.05) Indians respectively. Multivariate logistic regression analysis that Malay, Indian were −842CC homozygotes = 0.198, 0.089, 0.620), −842GC heterozygotes 0.492, 0.176, 0.377) and...
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