Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: prognostic relevance of extent of 11q deleted nuclei inside leukemic clone.

摘要: Deletion on the long arm of chromosome 11 occurs in 5-20% chronic lymphocytic leukaemia (CLL) patients. We analysed clinical-biological characteristics 131 CLL patients carrying 11q deletion documented before therapy (de novo deleted CLL). De were characterized by high frequencies unmutated immunoglobulin variable heavy genes, multiple fluorescence situ hybridization aberrations and lymph node involvement. Factors significantly associated with shorter time to first treatment (TTFT) advanced Binet stages, white blood cell count, increased ?2 -microglobulin levels, 17p addition, splenomegaly more extensive lymphadenopathy. found that <25% nuclei (n?=?22) experienced longer TTFT compared ?25% (n?=?87; median TTFT, 40 vs. 14?months, p?=?0.011) also showed better response treatments (complete response, 50% 21%, p?=?0.016). The variables identified multivariate analysis as independently reduced stages [hazard ratio (HR) 4.69; p?