Overexpression of suppressor of IKBKE 1 is associated with vincristine resistance in colon cancer cells.
作者： Chun-Peng Zhao , Zhong-Jie Xu , Qing Guo , Yun-Xiao Li , Xiang-Zheng Gao
DOI: 10.3892/BR.2016.759
关键词: Molecular medicine 、 Cancer 、 Internal medicine 、 Carcinogenesis 、 Cell cycle 、 Blot 、 Cancer research 、 Oncogene 、 Colorectal cancer 、 Oncology 、 Biology 、 IKBKE
摘要: In a previous study, the suppressor of IKBKE 1 expression level was confirmed to be higher in vincristine (VCR)-resistant HCT-8 (HCT-8/V) colon cancer cells than non-VCR-resistant cells. current VCR-resistant investigated further. and HCT-8/V human were used, polymerase chain reaction (PCR) primers designed amplify gene. Fluorescence reverse transcription-quantitative PCR (RT-qPCR) performed detect differences between sensitive drug-resistant cell lines. Western blotting further observe expression. Based on RT-qPCR western blot results, observed markedly cells, this difference significant (P<0.05). Thus, identified associated with resistance VCR.
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