In vivo imaging of neuroinflammation: a comparative study between [ 18 F]PBR111, [ 11 C]CLINME and [ 11 C]PK11195 in an acute rodent model
作者： Nadja Van Camp , Raphael Boisgard , Bertrand Kuhnast , Benoit Thézé , Thomas Viel
DOI: 10.1007/S00259-009-1353-0
关键词: Pathology 、 Preclinical imaging 、 Benzodiazepine 、 Pharmacology 、 Central nervous system 、 Receptor 、 Inflammation 、 Neuroinflammation 、 Translocator protein 、 Positron emission tomography 、 Medicine
摘要: Purpose The key role of neuroinflammation in acute and chronic neurological disorders has stimulated the search for specific radiotracers targeting peripheral benzodiazepine receptor (PBR)/18 kDa translocator protein (TSPO), a hallmark neuroinflammation. Here we evaluate new radiotracer positron emission tomography (PET) [18F]PBR111 rodent model inflammation compare it with [11C]CLINME, an 11C-labelled tracer same chemical family, isoquinolinic carboxamide [11C]PK11195.
manchester.ac.uk
springer.com
core.ac.uk参考文章(22)
Annelaure Damont, Françoise Hinnen, Bertrand Kuhnast, Marie‐Anne Schöllhorn‐Peyronneau, Michelle James, Christopher Luus, Bertrand Tavitian, Michael Kassiou, Frédéric Dollé, Radiosynthesis of [18F]PBR111, a selective radioligand for imaging the translocator protein (18 kDa) with PET Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 51, pp. 435- 439 ,(2008) , 10.1002/JLCR.1523
Jun Maeda, Makoto Higuchi, Motoki Inaji, Bin Ji, Eisuke Haneda, Takashi Okauchi, Ming-Rong Zhang, Kazutoshi Suzuki, Tetsuya Suhara, Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor Brain Research. ,vol. 1157, pp. 100- 111 ,(2007) , 10.1016/J.BRAINRES.2007.04.054
Hervé Boutin, Fabien Chauveau, Cyrille Thominiaux, Bertrand Kuhnast, Marie-Claude Grégoire, Sébastien Jan, Régine Trebossen, Frédéric Dollé, Bertrand Tavitian, Filomena Mattner, Andrew Katsifis, In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors. Glia. ,vol. 55, pp. 1459- 1468 ,(2007) , 10.1002/GLIA.20562
Kazuhiko Yanamoto, Ming-Rong Zhang, Katsushi Kumata, Akiko Hatori, Maki Okada, Kazutoshi Suzuki, In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats Neuroscience Letters. ,vol. 428, pp. 59- 63 ,(2007) , 10.1016/J.NEULET.2007.09.050
Masao Imaizumi, Emmanuelle Briard, Sami S. Zoghbi, Jonathan P. Gourley, Jinsoo Hong, Yota Fujimura, Victor W. Pike, Robert B. Innis, Masahiro Fujita, Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors ☆ NeuroImage. ,vol. 39, pp. 1289- 1298 ,(2008) , 10.1016/J.NEUROIMAGE.2007.09.063
Fabien Chauveau, Hervé Boutin, Nadja Van Camp, Frédéric Dollé, Bertrand Tavitian, Nuclear imaging of neuroinflammation: A comprehensive review of [ 11C]PK11195 challengers European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 35, pp. 2304- 2319 ,(2008) , 10.1007/S00259-008-0908-9
Bin Ji, Jun Maeda, Makoto Sawada, Maiko Ono, Takashi Okauchi, Motoki Inaji, Ming-Rong Zhang, Kazutoshi Suzuki, Kiyoshi Ando, Matthias Staufenbiel, John Q Trojanowski, Virginia MY Lee, Makoto Higuchi, Tetsuya Suhara, Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. The Journal of Neuroscience. ,vol. 28, pp. 12255- 12267 ,(2008) , 10.1523/JNEUROSCI.2312-08.2008
Christopher J. R. Fookes, Tien Q. Pham, Filomena Mattner, Ivan Greguric, Christian Loc’h, Xiang Liu, Paula Berghofer, Rachael Shepherd, Marie-Claude Gregoire, Andrew Katsifis, Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission Tomography Journal of Medicinal Chemistry. ,vol. 51, pp. 3700- 3712 ,(2008) , 10.1021/JM7014556
Petra Schweinhardt, Peter Fransson, Lars Olson, Christian Spenger, Jesper L.R. Andersson, A template for spatial normalisation of MR images of the rat brain. Journal of Neuroscience Methods. ,vol. 129, pp. 105- 113 ,(2003) , 10.1016/S0165-0270(03)00192-4
H. Boutin, F. Chauveau, C. Thominiaux, M.-C. Gregoire, M. L. James, R. Trebossen, P. Hantraye, F. Dolle, B. Tavitian, M. Kassiou, 11C-DPA-713: A Novel Peripheral Benzodiazepine Receptor PET Ligand for In Vivo Imaging of Neuroinflammation The Journal of Nuclear Medicine. ,vol. 48, pp. 573- 581 ,(2007) , 10.2967/JNUMED.106.036764