Hormonal Signaling to the Brain for the Control of Feeding/Energy Balance

作者: R.M. Twyman

DOI: 10.1016/B978-008045046-9.01174-8

关键词: HypothalamusHormoneEndocrinologyAppetiteGhrelinLeptinBiologyEnergy homeostasisAdipose tissueEnergy balanceInternal medicine

摘要: Energy homeostasis – the balance between energy intake and expenditure is key principle underlying weight fluctuation in humans. A network of hormonal mechanisms links control appetite to feeding behavior adiposity. host signals produced digestive system, adipose tissue, brain interact modify physiological responses involved maintaining an balance. This article summarizes major regions, hormones, circuits that describes how malfunctions this delicately balanced system can lead metabolic disorders obesity.

参考文章(9)
J. M. Friedman, Obesity in the new millennium. Nature. ,vol. 404, pp. 632- 634 ,(2000) , 10.1038/35007504
Akio Inui, Ghrelin: An orexigenic and somatotrophic signal from the stomach Nature Reviews Neuroscience. ,vol. 2, pp. 551- 560 ,(2001) , 10.1038/35086018
Bruce M. Spiegelman, Jeffrey S. Flier, Obesity and the Regulation of Energy Balance Cell. ,vol. 104, pp. 531- 543 ,(2001) , 10.1016/S0092-8674(01)00240-9
Andrew A Butler, Roger D Cone, Knockout models resulting in the development of obesity Trends in Genetics. ,vol. 17, pp. S50- S54 ,(2001) , 10.1016/S0168-9525(01)02481-7
Jason G. Halford, Pharmacology of appetite suppression: implication for the treatment of obesity. Current Drug Targets. ,vol. 2, pp. 353- 370 ,(2001) , 10.2174/1389450013348209
Kevin G. Murphy, Stephen R. Bloom, Gut hormones and the regulation of energy homeostasis Nature. ,vol. 444, pp. 854- 859 ,(2006) , 10.1038/NATURE05484
M. D. Klok, S. Jakobsdottir, M. L. Drent, The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obesity Reviews. ,vol. 8, pp. 21- 34 ,(2007) , 10.1111/J.1467-789X.2006.00270.X
Shefali Dham, Mary A Banerji, The brain-gut axis in regulation of appetite and obesity. Pediatric endocrinology reviews. pp. 544- ,(2006)