Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection.

摘要: Background:  Genital Chlamydia (C) trachomatis infection has been recognized as the single most common cause of pelvic inflammatory disease leading to severe tubal damage, ectopic pregnancy, infertility and hydrosalpinx. However, mechanism underlying formation hydrosalpinx induced by C. remains largely unknown. We performed this study determine involvement cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel that regulates epithelial electrolyte fluid secretion, in formation. Methods:  Western blot analysis was used CFTR expression hydrosalpinges were seen on ultrasound scans infertile assisted reproduction treatment patients. Correlation with done testing patients' sera for immunoglobulin G antibody titer using Capita enzyme-linked immunosorbent assay based kit. further verified rat model confirmed mutant (CFTRtm1Unc) mice. Results:  Here we report up-regulated tissues patients detectable serum levels (immunoglobulin G). In model, increased accumulation could be observed uterine horns infected elementary bodies, which reversed antibiotics treatment. trachomatis–infected CFTRtm1Unc mice, however, no observed. Conclusion:  These findings suggest pathogenesis may provide grounds better strategy improve outcome