A Novel In Vivo Model to Study Impaired Tissue Regeneration Mediated by Cigarette Smoke

摘要: Cigarette smoke is associated with several pathologies including chronic respiratory diseases and cancer. In addition, exposure to cigarette correlated impaired wound healing, where a significant decrease in the regenerative capacity of smokers well documented broadly considered negative risk factor after trauma or surgery. So far, some vitro vivo models have been described study how diminishes potential different organisms. However, although useful, many these are difficult expensive implement do not allow high-throughput screening approaches. order establish reliable accessible model, we evaluated effects extract (CSE) on zebrafish development regeneration. this work, embryos larvae were exposed low doses aqueous CSE showing severe developmental abnormalities dose-dependent manner. Furthermore, when adult subjected caudal fin amputation, observed animals CSE. The effect was exacerbated male aged fish compared female young establishment model assess consequences its animal physiology could provide new tool underlying mechanisms involved tissue regeneration, aid novel approaches treat complications toxicity.