Predicting Intracerebral Hemorrhage Growth With the Spot Sign: The Effect of Onset-to-Scan Time.

摘要: Background and Purpose— Hematoma expansion after acute intracerebral hemorrhage is common associated with early deterioration poor clinical outcome. The computed tomographic angiography (CTA) spot sign a promising predictor of expansion; however, frequency predictive values are variable across studies, possibly because differences in onset-to-CTA time. We performed patient-level meta-analysis to define the relationship between time ability sign. Methods— completed systematic review for studies CTA hematoma expansion. subsequently pooled data on significant according 5 predefined categorized times. calculated spot-sign both as raw frequency-adjusted rates. Results— Among 2051 identified, 12 met our inclusion criteria. Baseline volume, status, time-to-CTA were available 1176 patients, 1039 patients had follow-up tomographies analysis. overall was 26%, decreasing from 39% within 2 hours onset 13% beyond 8 ( P =0.004), positive 53% 33%. Conclusions— inversely related Furthermore, value decreases increases. Our results offer more precise risk stratification will help refine prediction rules