Vernier threshold in patients with schizophrenia and in their unaffected siblings.
作者： Szabolcs Kéri , Oguz Kelemen , György Benedek , Zoltán Janka
DOI: 10.1037/0894-4105.18.3.537
关键词: Vernier acuity 、 Audiology 、 Retinal 、 Schizophrenia 、 Developmental psychology 、 Psychology 、 Psychosis 、 Receptive field 、 Endophenotype 、 Sibling 、 Parvocellular cell
摘要: The aim of this study was to investigate magnocellular (M) and parvocellular (P) visual functions in nonmedicated patients with schizophrenia their unaffected siblings. Possible abnormalities cortical integration retinal receptive fields also were addressed. Twenty-two schizophrenia, siblings, 20 age- IQ-matched healthy control subjects received 4 vernier acuity tasks (blue-on-yellow, frequency-doubling, achromatic low high contrast conditions) which they asked detect the spatial alignment dots gratings. Results revealed that siblings showed selective dysfunctions frequency-doubling conditions, devoted M pathways. In isoluminant blue-on-yellow there no significant differences between experimental groups. These results suggest deficit pathway is an endophenotype schizophrenia.
sci-hub.st 参考文章(50)
Selective deficits in visual perception and recognition in schizophrenia American Journal of Psychiatry. ,vol. 153, pp. 687- 692 ,(1996) , 10.1176/AJP.153.5.687
Barry, D. Schwartz, Neurophysiologic mechanisms of attention: a selective review of early information processing in schizophrenics Frontiers in Bioscience. ,vol. 6, pp. d120- ,(2001) , 10.2741/SCHWARTZ
Melvyn A. Goodale, Richard J. W. Mansfield, David Ingle, Analysis of visual behavior MIT Press. ,(1982)
Brad Fortune, Allison M. McKendrick, Andrew J. Anderson, Chris A. Johnson, Elevated vernier acuity thresholds in glaucoma. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 1393- 1399 ,(2002)
L. G. Ungerleider, Two cortical visual systems Analysis of Visual Behavior. pp. 549- 586 ,(1982)
Kristin S. Cadenhead, Yulya Serper, David L. Braff, Transient versus sustained visual channels in the visual backward masking deficits of schizophrenia patients Biological Psychiatry. ,vol. 43, pp. 132- 138 ,(1998) , 10.1016/S0006-3223(97)00316-8
Szabolcs Kéri, Andrea Antal, György Szekeres, György Benedek, Zoltán Janka, Visual information processing in patients with schizophrenia: evidence for the impairment of central mechanisms. Neuroscience Letters. ,vol. 293, pp. 69- 71 ,(2000) , 10.1016/S0304-3940(00)01473-7
David Omtzigt, Angélique W Hendriks, Herman H.J Kolk, Evidence for magnocellular involvement in the identification of flanked letters. Neuropsychologia. ,vol. 40, pp. 1881- 1890 ,(2002) , 10.1016/S0028-3932(02)00069-6
Brooke A Armstrong, Helen J Neville, Steven A Hillyard, Teresa V Mitchell, Auditory deprivation affects processing of motion, but not color. Cognitive Brain Research. ,vol. 14, pp. 422- 434 ,(2002) , 10.1016/S0926-6410(02)00211-2
Yue Chen, Germán P. Palafox, Ken Nakayama, Deborah L. Levy, Steven Matthysse, Philip S. Holzman, Motion Perception in Schizophrenia Archives of General Psychiatry. ,vol. 56, pp. 149- 154 ,(1999) , 10.1001/ARCHPSYC.56.2.149