Dietary vitamin e in an atherogenic hamster model

摘要: Regular consumption of fruits, vegetables and cereals moderates development coronary heart disease atherosclerosis in humans, possibly as a result antioxidants present these foods. The aim this study was to develop hamster model sufficiently sensitive test the effects nutritional rather than pharmacological amounts food components on atherosclerosis. effect vitamin E aortic lipid deposition investigated hamsters fed hypercholesterolemic diet containing per kilogram 2 g cholesterol, 90 butterfat, 35 E-stripped corn oil, 25 fish oil either minimum requirement 3 international units (IU) or 30 IU. After weeks, lipoprotein cholesterol fractions did not differ between groups, 6:1 LDL-cholesterol : HDL-cholesterol ratio atherogenic. Early measured by staining arch sections with red O quantified photomicroscopy color-scanning technique. area deposits IU group (7.9 ± 1.3%, mean SEM) 58% less (18.7 4.4%, p < 0.03). Hamsters mixture saturated n-6 n-3 polyunsaturated fatty acids plus became were respect This provides tool atheroprotective individual vivo.