Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.

摘要: Abstract Background: Interleukin-17 (IL-17) is a novel cytokine secreted by activated human memory CD4+ T cells. In vivo IL-17 recruits neutrophils into the airways via release of CXC chemokines (interleukin-8) from bronchial epithelial Since are implicated in pathogenesis chronic obstructive pulmonary disease (COPD), bronchitis (CB) and asthma, we hypothesized that there would be increased concentration these patients. To test this hypothesis, measured levels induced sputum COPD patients, asthmatics compared them with healthy controls. Methods : Levels were ELISA method 19 COPD, 16 CB, 10 asthma 11 control subjects. Airway responsiveness to methacholine was performed people FEV1 higher than 70% predicted. Results: There no significant differences between group other groups. However, patients significantly lower ( P =0.004) CB =0.01) Medians (ranges) as follows: asthma—37.6 pg/ml (18.8–55.7 pg/ml), 29.3 (18.8–49.7 pg/ml) 24.6 (0-34.1pg/ml). Comparison subjects (PC 20 >8 mg/ml) hyperreactivity, which consisted whose PC less 8 mg/ml, revealed second =0.02). Also, =0.02) asthmatic hyperreactivity Moreover all studied correlated negatively r =−0.51, =0.002). Conclusions: According our results probably not involved stable but it may play role airway hyperresponsiveness.