BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.

摘要: Bromodomain PHD finger transcription factor (BPTF), a core subunit of nucleosome-remodeling (NURF) complex, plays an important role in chromatin remodeling. However, its precise function and molecular mechanism involved hepatocellular carcinoma (HCC) growth are still poorly defined. Here, we demonstrated the tumor-promoting BPTF HCC progression. was highly expressed cells tumor tissues patients compared with normal liver tissues. Knockdown inhibited cell proliferation, colony formation stem cell-like traits cells. In addition, knockdown effectively sensitized anti-tumor effect chemotherapeutic drugs induced more apoptosis Consistently, xenograft mouse model also suppressed metastasis accompanied by suppression cancer (CSC)-related protein markers. Moreover, study showed that realized transcriptionally regulating expression human telomerase reverse transcriptase (hTERT). Furthermore, found high displayed hTERT expression, or level positively correlated advanced malignancy poor prognosis patients. Collectively, our results demonstrate promotes targeting suggest BPTF-hTERT axis maybe novel potential therapeutic target HCC.