Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
作者： Si-tong Li , Qi Dai , Shu-xian Zhang , Ya-jun Liu , Qiu-qiong Yu
DOI: 10.1038/APS.2017.143
关键词: Signal transduction 、 Inflammation 、 p38 mitogen-activated protein kinases 、 Pharmacology 、 Phosphorylation 、 NF-κB 、 Protein kinase B 、 Chemistry 、 Ulinastatin 、 PI3K/AKT/mTOR pathway
摘要: … of UTI on LPS-induced RAW264.7 cells can be attributed to the activation of the PI3K/Akt-Nrf2 axis and the inhibition of the Thr183 p-JNK/NF-κB axis. UTI effectively suppressed LPS-…
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