Assessing blood granulocyte colony-stimulating factor as a potential biomarker of acute traumatic brain injury in mice and humans

摘要: Previous work has found that serum G-CSF was acutely elevated in mice 24h but not one week after controlled cortical impact (CCI). The purpose of this study to investigate whether blood correlates with the brain cytokines CCI and also if it traumatic injury (TBI) humans. Here, we undergoing CCI, a procedure induces direct brain, correlated directly or indirectly several cytokines, indicating is useful marker for neuroinflammation TBI. A pilot humans (phase I, n=19) confirmed plasma on day 1 (p<0.001) TBI returned baseline by week. In second human sample II) (n=80), peaks about 12h arriving emergency department (41.6+/-5.4 pg/ml). Aging weakly associated (p<0.05) less robust elevation G-CSF, there no difference gender. ISS, measure total severity injury, degree (r=.419; p<0.05), head (via AIS) did not. latter may have been because statistically narrow range injuries among our cases high number diagnosed closed (a non-codable diagnosis). conclusion, be biomarker TBI, correlating animal model studies time since injury. As such, determining occurred within last 24h.