Effect of acute alterations in inspired oxygen tension on methacholine induced bronchoconstriction in patients with asthma.
作者： K. D. Dagg , L. J. Thomson , R. A. Clayton , S. G. Ramsay , N. C. Thomson
DOI: 10.1136/THX.52.5.453
关键词: Medicine 、 Oxygen saturation (medicine) 、 Inhalation 、 Bronchoconstriction 、 Breathing 、 Methacholine 、 Asthma 、 Hyperoxia 、 Lung volumes 、 Anesthesia
摘要: BACKGROUND: Recent in vitro and vivo studies animals have suggested that ambient oxygen tension may influence airway responsiveness to bronchoconstrictor stimuli. These observations relevance the management of acute exacerbations asthma. The present were designed examine inspired (Fio2 1.0, 0.21, 0.15) on methacholine-induced broncho-constriction patients with METHODS: In a dual study two groups asthmatic performed methacholine inhalation challenges breathing either air 0.21) or hypoxic gas mixture 1 hyperoxia 1.0) 2. gases administered through closed circuit randomised double blind fashion. PC20 values (dose causing 20% fall forced expiratory volume one second (FEV1) calculated after each challenge by linear interpolation from logarithmic dose response curve. Plasma catecholamine levels measured before as well heart rate, saturation, percentage end tidal carbon dioxide levels. RESULTS: geometric mean value for was significantly lower day than normoxic (mean difference 2.88 mg/ml (95% CI 1.4 5.3); p
sci-hub.se 参考文章(19)
M. Hills, P. Armitage, The two-period cross-over clinical trial. British Journal of Clinical Pharmacology. ,vol. 8, pp. 7- 20 ,(1979) , 10.1111/J.1365-2125.1979.TB05903.X
Michael T. Newhouse, Margaret R. Becklake, Peter T. Macklem, Maurice McGregor, Effect of alterations in end-tidal CO2 tension on flow resistance Journal of Applied Physiology. ,vol. 19, pp. 745- 749 ,(1964) , 10.1152/JAPPL.1964.19.4.745
C. F. O'Cain, M. J. Hensley, E. R. McFadden, R. H. Ingram, Pattern and mechanism of airway response to hypocapnia in normal subjects Journal of Applied Physiology. ,vol. 47, pp. 8- 12 ,(1979) , 10.1152/JAPPL.1979.47.1.8
James G. Watt, Paul R. Dumke, Julius H. Comroe, EFFECTS OF INHALATION OF 100 PER CENT AND 14 PER CENT OXYGEN UPON RESPIRATION OF UNANESTHETIZED DOGS BEFORE AND AFTER CHEMORECEPTOR DENERVATION American Journal of Physiology-Legacy Content. ,vol. 138, pp. 610- 617 ,(1943) , 10.1152/AJPLEGACY.1943.138.4.610
J. D'Brot, T. Ahmed, Hypoxia-induced enhancement of nonspecific bronchial reactivity: role of leukotrienes. Journal of Applied Physiology. ,vol. 65, pp. 194- 199 ,(1988) , 10.1152/JAPPL.1988.65.1.194
Sterling Gm, The mechanism of bronchoconstriction due to hypocapnia in man. Clinical Science. ,vol. 34, pp. 105- ,(1968)
Trevor W. Astin, The Relationships between Arterial Blood Oxygen Saturation, Carbon Dioxide Tension, and pH and Airway Resistance during 30 Per Cent Oxygen Breathing in Patients with Chronic Bronchitis with Airway Obstruction1, 2 The American review of respiratory disease. ,vol. 102, pp. 382- ,(1970) , 10.1164/ARRD.1970.102.3.382
Bruce Marchette, Tahir Ahmed, Hypoxia enhances nonspecific bronchial reactivity The American review of respiratory disease. ,vol. 132, pp. 839- 844 ,(1985) , 10.1164/ARRD.1985.132.4.839
Robert D. Dripps, Julius H. Comroe, The effect of the inhalation of high and low oxygen concentrations on respiration, pulse rate, ballistocardiogram and arterial oxygen saturation (oximeter) of normal individuals. American Journal of Physiology. ,vol. 149, pp. 277- 291 ,(1947) , 10.1152/AJPLEGACY.1947.149.2.277
M Okayama, K Sekizawa, W Hida, T Takishima, C Inoue, H Inoue, Breathing 30 per cent oxygen attenuates bronchial responsiveness to methacholine in asthmatic patients European Respiratory Journal. ,vol. 2, pp. 506- 512 ,(1989)