Aspects of Bacterial Enterotoxins Other than Cholera on Intestinal Permeability

摘要: Cholera enterotoxin (CT) (Holmgren and Lonnroth 1980) has been the major stimulus for studies of other bacterial enterotoxins. Its features are well described in Chap. 26. Studies labile toxin (LT) Escherichia coli (Field 1974), demonstrating that its mode action is very similar to CT, recent stable (ST) E. et al. 1978; Staples which have demonstrated ST specifically activates guanylate cyclase intestinal mucosal cells, developments Many enterotoxins identified, but either not as fully purified LT or their on transport processes less defined. Information role significance diarrheal disease also limited. Definition specific will, however, be importance several reasons, (a) They may help define normal physiologic a manner by CT-activated chloride secretion, (b) Other toxins cause fluid electrolyte secretion activation secretory distinct from those dependent cAMP cGMP systems; instance, no yet identified mechanisms accompanying serotonin-induced there clear knowledge whether filtrative factor toxin-mediated process.