Diabetes mellitus ☆: A hypercoagulable state

摘要: Eighty percent of patients with diabetes mellitus die a thrombotic death. Seventy-five these deaths is due to cardiovascular complications, and the remainder cerebrovascular events peripheral vascular complications. Vascular endothelium, primary defense against thrombosis, abnormal in diabetes. Endothelial abnormalities undoubtedly play role enhanced activation platelets clotting factors seen Coagulation markers, such as prothrombin fragment 1+2 thrombin-anti-thrombin complexes, are elevated The plasma levels many including fibrinogen, factor VII, VIII, XI, XII, kallikrein, von Willebrand Conversely, level anticoagulant protein C (PC) decreased. fibrinolytic system, means removing clots, relatively inhibited clot structures that more resistant degradation an increase plasminogen activator inhibitor type 1 (PAI-1). Increased circulating platelet aggregates, increased aggregation response agonists, contractile force (PCF), presence higher release products, beta-thromboglobulin, 4, thromboxane B(2), demonstrate hyperactivity This constellation findings supports clinical observation hypercoagulable state. article briefly reviews published evidence for this conclusion putative roles played by hyperglycemia hyperinsulinemia its development.