Laboratory Tests in Liver Diseases

作者: Yoshio Sumida , Yoshihiro Kamada , Masaki Iwai , Paul Y. Kwo , Masashi Yoneda

DOI: 10.1007/978-981-13-6806-6_2

关键词: Nonalcoholic fatty liver diseaseLiver cancerGastroenterologyCirrhosisHepatic fibrosisGold standard (test)Liver diseaseLiver biopsyInternal medicineMedicineFibrosis

摘要: Laboratory tests for evaluating liver diseases are essential. This chapter reviews routine biochemical and disease-specific laboratory tests. Algorithms assessing acute chronic hepatobiliary enzyme elevation suggested. The degree of hepatic fibrosis has been established to be the most significant determinant mortality/morbidity in diseases. Liver biopsy is gold standard diagnosis fibrosis, but it several drawbacks such as invasiveness, cost, risk. We here review noninvasive parameters, including markers, scoring systems. Nonalcoholic fatty disease (NAFLD) becoming common all over world. Diagnostic algorithm NAFLD also detect severe (stage 3/4). Severity cirrhosis was usually assessed by Child-Pugh score, MELD ALBI grade. discuss significance tumor markers α-fetoprotein (AFP), fucosylated AFP, des-gamma-carboxyprothrombin order cancer evaluate its treatment efficacy.

参考文章(145)
Yoshikazu Murawaki, Yujiro Ikuta, Yuuko Nishimura, Masahiko Koda, Hironaka Kawasaki, Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis. Journal of Hepatology. ,vol. 23, pp. 145- 152 ,(1995) , 10.1016/0168-8278(95)80328-9
Jennifer R. Kramer, Steven M. Asch, Matthew Bidwell Goetz, Angelique Zeringue, Peter Richardson, Hashem B. El–Serag, Fasiha Kanwal, Tuyen Hoang, Increasing Prevalence of HCC and Cirrhosis in Patients With Chronic Hepatitis C Virus Infection Gastroenterology. ,vol. 140, pp. 1182- 1188 ,(2011) , 10.1053/J.GASTRO.2010.12.032
Koichi Honke, Eiji Miyoshi, Michela Tonetti, Akinori Kasahara, Susumu Nakahara, Takatoshi Kitada, Cong-Xiao Gao, Kiyoshi Kawano, Naoyuki Taniguchi, Norio Hayashi, Masatsugu Hori, Katsuhisa Noda, Harumasa Yoshihara, Jianguo Gu, Kunio Suzuki, Kiyoshi Yoshikawa, Relationship between Elevated FX Expression and Increased Production of GDP-l-Fucose, a Common Donor Substrate for Fucosylation in Human Hepatocellular Carcinoma and Hepatoma Cell Lines Cancer Research. ,vol. 63, pp. 6282- 6289 ,(2003)
J Filmus, J G Church, R N Buick, Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine. Molecular and Cellular Biology. ,vol. 8, pp. 4243- 4249 ,(1988) , 10.1128/MCB.8.10.4243
Valeria R Mas, Robert A Fisher, Kellie J Archer, Daniel G Maluf, Proteomics and liver fibrosis: identifying markers of fibrogenesis. Expert Review of Proteomics. ,vol. 6, pp. 421- 431 ,(2009) , 10.1586/EPR.09.59
S Moller, J H Henriksen, Cardiovascular complications of cirrhosis Postgraduate Medical Journal. ,vol. 85, pp. 44- 54 ,(2008) , 10.1136/GUT.2006.112177
Hiroshi Kojima, Yasushi Hongo, Hideharu Harada, Toshihiro Inoue, Katsuhiko Miyaji, Motomi Kashiwagi, Tetsuya Momose, Yoshifumi Arisaka, Hideo Fukui, Seiyo Murai, Hajime Tokita, Hiroshi Kamitsukasa, Michiyasu Yagura, Kenichi Katsu, Long-term histological prognosis and serum fibrosis markers in chronic hepatitis C patients treated with interferon. Journal of Gastroenterology and Hepatology. ,vol. 16, pp. 1015- 1021 ,(2001) , 10.1046/J.1440-1746.2001.02569.X
Hendrik Vilstrup, Piero Amodio, Jasmohan Bajaj, Juan Cordoba, Peter Ferenci, Kevin D. Mullen, Karin Weissenborn, Philip Wong, Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver Hepatology. ,vol. 60, pp. 715- 735 ,(2014) , 10.1002/HEP.27210
Mariana Capurro, Ian R Wanless, Morris Sherman, Gerrit Deboer, Wen Shi, Eiji Miyoshi, Jorge Filmus, Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma Gastroenterology. ,vol. 125, pp. 89- 97 ,(2003) , 10.1016/S0016-5085(03)00689-9