Measuring and Reversing the Effect of Non-Vitamin K Antagonist Oral Anticoagulants (NOACs)

Partha Sardar, Saurav Chatterjee, Shobhana Chaudhari, Gregory Y. H. Lip, New Oral Anticoagulants in Elderly Adults: Evidence from a Meta‐Analysis of Randomized Trials Journal of the American Geriatrics Society. ,vol. 62, pp. 857- 864 ,(2014) , 10.1111/JGS.12799

Abdel-Baset Halim, Meyer M. Samama, Jeanne Mendell, Ex vivo reversal of the anticoagulant effects of edoxaban Thrombosis Research. ,vol. 134, pp. 909- 913 ,(2014) , 10.1016/J.THROMRES.2014.07.036

Jack E. Ansell, Sasha H. Bakhru, Bryan E. Laulicht, Solomon S. Steiner, Michael Grosso, Karen Brown, Victor Dishy, Robert J. Noveck, James C. Costin, Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban New England Journal of Medicine. ,vol. 371, pp. 2141- 2142 ,(2014) , 10.1056/NEJMC1411800

Joachim Stangier, Sebastian Haertter, Karl-Heinz Liesenfeld, Wolfgang Wienen, Martin Feuring, Andreas Clemens, Joanne van Ryn, Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity Thrombosis and Haemostasis. ,vol. 103, pp. 1116- 1127 ,(2010) , 10.1160/TH09-11-0758

Gabriele Rohde, Gertrud Stratmann, Christian Hesse, Natalie Herth, Stephan Schwers, Elisabeth Perzborn, Edelgard Lindhoff-Last, Helen Mani, Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin Thrombosis and Haemostasis. ,vol. 108, pp. 191- 198 ,(2012) , 10.1160/TH11-12-0832

Jessica L Mega, Eugene Braunwald, Stephen D Wiviott, Jean-Pierre Bassand, Deepak L Bhatt, Christoph Bode, Paul Burton, Marc Cohen, Nancy Cook-Bruns, Keith AA Fox, Shinya Goto, Sabina A Murphy, Alexei N Plotnikov, David Schneider, Xiang Sun, Freek WA Verheugt, C Michael Gibson, None, Rivaroxaban in Patients with a Recent Acute Coronary Syndrome The New England Journal of Medicine. ,vol. 366, pp. 9- 19 ,(2012) , 10.1056/NEJMOA1112277

Meyer Michel Samama, Jeanne Mendell, Céline Guinet, Léna Le Flem, Satoshi Kunitada, In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux Thrombosis Research. ,vol. 129, ,(2012) , 10.1016/J.THROMRES.2011.07.026

Tuukka A Helin, Anja Pakkanen, Riitta Lassila, Lotta Joutsi-Korhonen, Laboratory Assessment of Novel Oral Anticoagulants: Method Suitability and Variability between Coagulation Laboratories Clinical Chemistry. ,vol. 59, pp. 807- 814 ,(2013) , 10.1373/CLINCHEM.2012.198788

Elise S. Eerenberg, Pieter W. Kamphuisen, Meertien K. Sijpkens, Joost C. Meijers, Harry R. Buller, Marcel Levi, Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. ,vol. 124, pp. 1573- 1579 ,(2011) , 10.1161/CIRCULATIONAHA.111.029017

Gines Escolar, Eduardo Arellano-Rodrigo, Irene Lopez-Vilchez, Patricia Molina, Juan Sanchis, Joan Carles Reverter, Xavier Carne, Joan Cid, Jaume Villalta, Dolors Tassies, Ana M. Galan, Maribel Diaz-Ricart, Reversal of rivaroxaban-induced alterations on hemostasis by different coagulation factor concentrates – in vitro studies with steady and circulating human blood. Circulation. ,vol. 79, pp. 331- 338 ,(2015) , 10.1253/CIRCJ.CJ-14-0909