Allosteric Modulation of Glutamate Transporters

摘要: Glutamate is the predominant excitatory neurotransmitter in mammalian central nervous system (CNS) and mediates a wide variety of physiological functions, but failure to adequately control extracellular glutamate concentrations can lead excessive neurotransmission cell death. transporters contribute maintaining thereby play an important role regulating dynamics neurotransmission. In this chapter we will briefly discuss structure function then focus on how activity be allosterically regulated by endogenous factors also pharmacological agents may impact glutamatergic This addressed terms what compounds have been identified as allosteric regulators, structural specificity interactions, where binding sites are located transporters, ligand these influence transporter function.