Accessory molecules involved in antigen-mediated cytolysis and lymphokine production by cytotoxic T lymphocyte subsets. I. Identification of functions for the T cell surface molecules Ly-6C and Thy-1.

摘要: The murine T cell surface molecules Ly-6C and Thy-1 are genetically structurally distinct, yet they share two interesting properties: both attached to the plasma membrane through a glycophosphatidylinositol linkage, some mAb reactive with these can activate cells. Although for appear mimic function of physiologic ligands, direct evidence existence putative ligands has not been presented. In this report, we describe CTL clones that use as accessory activation cytolysis production IFN-gamma based on inhibition functions mAb. These studies were facilitated by derivation nonactivating hamster IgM specific Ly-6C. include subpopulation previously described CD8+ alloreactive inhibited CD8, TCR-alpha/beta+ clone HSV glycoprotein D, CD4-CD8- TCR-gamma/delta+ I. role in target recognition is degree tissue-specific respect APC/target cell. A appears inhibit prevention adhesion between effector cells This most date functional ligand