A novel technique for the evaluation of mechanical pain and hyperalgesia.

作者: Lothar U.E. Kohllöffel , Martin Koltzenburg , Hermann O. Handwerker

DOI: 10.1016/0304-3959(91)90037-X

关键词: Biomedical engineeringHyperalgesiaPsychophysicsMedicineReflexSensationReproducibilityStimulus (physiology)NociceptorAnesthesiaStimulation

摘要: Abstract We describe a new technique which is useful for the evaluation of mechanically induced pain and hyperalgesia. Light metal cylinders are guided accelerated in barrel. On impact against skin they elicit brief sensation pain. This method allows application wide range controllable innocuous noxious velocities cylinder at variable stimulus repetition rates. The system sufficiently flexible to stimulate perpendicularly any area move rapidly adjacent target regions if desired. Psychophysical testing using magnitude estimation techniques revealed that thresholds were normally distributed. Over stimulation intensities monotonically increasing response functions obtained. Repeated showed good intra-individual reproducibility both threshold supramaximal ratings. was also determining time course mechanical hyperalgesia following painful stimulus. conclude evaluating psychophysical its changes tissue injury. may hold some promise quantifying altered sensitivity patients.

参考文章(21)
K.D. Keele, PAIN-SENSITIVITY TESTS: THE PRESSURE ALGOMETER The Lancet. ,vol. 263, pp. 636- 639 ,(1954) , 10.1016/S0140-6736(54)92347-8
Donald D. Price, James W. Hu, Ronald Dubner, Richard H. Gracely, Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses Pain. ,vol. 3, pp. 57- 68 ,(1977) , 10.1016/0304-3959(77)90035-5
Donald D. Price, Patricia A. McGrath, Amir Rafii, Barbara Buckingham, The validation of visual analogue scales as ratio scale measures for chronic and experimental pain Pain. ,vol. 17, pp. 45- 56 ,(1983) , 10.1016/0304-3959(83)90126-4
Walter Magerl, Götz Geldner, Hermann O. Handwerker, Pain and vascular reflexes in man elicited by prolonged noxious mechano-stimulation Pain. ,vol. 43, pp. 219- 225 ,(1990) , 10.1016/0304-3959(90)91075-T
Laurence Kocher, Fernand Anton, Peter W. Reeh, Hermann O. Handwerker, The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat Pain. ,vol. 29, pp. 363- 373 ,(1987) , 10.1016/0304-3959(87)90051-0