Evaluation of a breast cancer nomogram for predicting the likelihood of additional nodal metastases in patients with a positive sentinel node biopsy.
作者： Lucio Torelli , Fabrizio Zanconati , Franca Dore , Maura Tonutti , Marina Bortul
DOI:
关键词: Population 、 Cancer 、 Sentinel node 、 Retrospective cohort study 、 Oncology 、 Medicine 、 Breast cancer 、 Receiver operating characteristic 、 Radiology 、 Internal medicine 、 Nomogram 、 Axillary Lymph Node Dissection
摘要: AIM: Completion axillary lymph node dissection (CALND) performed as a standard procedure after positive sentinel biopsy (SLNB) in breast cancer patients results, almost 40-70% of cases, no additional nodes. A nomogram has been developed at Memorial Sloan Kettering Cancer Center (MSKCC) to predict the likelihood nonsentinel metastases (NSLNM) SLNB. Aim study was assess accuracy MSKCC our community population. MATERIAL OF STUDY: From retrospective database 276 we evaluated 62 consecutive cases who underwent CALND Patient and tumor characteristics were collected used calculate probability NSLNM. The tested by Receiver Operating Characteristic (ROC) curve. Area Under Curve (AUC), sensitivity specificity calculated for 10% cut-off value. RESULTS: Presence macrometastases (p=0.03) its extranodal extension (p=0.013) associated with NSLNM, while other patient not. measured AUC 0.67. showed 95% 14% specificity. We revised incorporating presence obtained new test improved (84%). DISCUSSION: modified predictive model is useful tool predicting NSLNM cohort may help decision regarding need completion dissection.
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