Cytokeratin 20-positive hepatocellular carcinoma.

摘要: The differential diagnosis between hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and metastatic colorectal adenocarcinoma (MCA) may be difficult when only based on morphology. For this purpose immunohistochemical analyses are often required, utilizing antibodies directed against CK8-18, Hep-Par1, glypican 3, CK7, CK19, CK20. Here we report a case of 65-year-old man who presented with clinical picture decompensated cirrhosis. Ultrasonography revealed two nodular areas in the right liver lobe. Liver needle biopsy micro-macronodular cirrhosis associated HCC trabecular pseudoglandular patterns. Immunohistochemically, tumour cells were diffusely positive for CK8-18 also immunostained by 3 Hep-Par1. Interestingly, diffuse strong staining CK20 was detected vast majority tumor cells, particularly showing pseudo-glandular pattern. No immunostaining CK7 CK19 found cells. behaved aggressively, rapid diffusion to whole liver. patient died from disease few months after presentation. These findings underline that interpretation expression alone among HCC, CC MCA should done caution because immunoreactivity not rule out HCC.