Acute and Subacute Toxicity of Methanol Extract of Phyllanthus Polyphyllus in Rats

摘要: The objective of the present study was to determine acute and subacute toxicity methanol extract Phyllanthus polyphyllus (MPP) using rats as experimental animals. In an study, MPP administered orally at doses 50, 500, 1000, 2000 mg/kg animals were observed for first two hours, 24 hours detect changes in behavioral responses also tremors, convulsion, salivation, diarrhea, lethargy, sleep coma monitored any mortality. 200, 500 1000 (low dose, intermediate dose high dose) 28 days. sacrificed on 29 th day various blood biochemical parameters measured. liver kidney processed. No mortalities occurred during studies did not cause death, even highest (2000 mg/kg). Thus, it found be safe. treatment show significant change weight hematological parameters. Only glucose level showed differences statistically (P<0.05), although values close those control group. results suggest that plant seems free toxic effects rats.