18F-FDG:18F-NaF PET/MR multi-parametric imaging with kinetics-based bone segmentation for enhanced dual-tracer PET quantification

作者: Nicolas A. Karakatsanis , Ronan Abgral , Gilles Boeykens , Marc R. Dweck , Philip M. Robson

DOI: 10.1109/NSSMIC.2016.8069386

关键词: Dual tracerCorrection for attenuationNuclear medicineSoft tissueRadiologyMulti parametricMolecular imagingBone segmentationPositron emission tomographyElectronic mailMedicine

摘要: Dual-tracer Positron Emission Tomography (PET) imaging involves the administration of two tracers for their co-registered evaluation within same subject and session. Previously, concept mixing 18F-Fluorodeoxyglucose (18F-FDG) 18F-sodium fluoride (18F-NaF or 18F-Fuoride) had been proposed in oncology to enable characterization a wider spectrum tumor types from single PET/CT exam. In this study, we are proposing an optimized F18-FDG:F18-NaF cocktail PET/MR framework multi-parametric assessments enhanced quantification. Our aims are: (i) benefit superior soft tissue MR and, thus, more accurate PET lesion localization, (ii) significantly reduce radiation exposure, therefore allowing multiple low-dose exams closely monitor treatment response oncology, (iii) facilitate evaluations cardiovascular diseases too, iv) exploit high bone uptake rate NaF compound improve attenuation correction. For that purpose, introduced clinically feasible single-bed dynamic 18F-FDG:18F-NaF protocol employing recommended dosage as single-tracer studies. Subsequently, images were robustly analyzed with Patlak method produce tracer Ki parametric images. Then, regions segmented included fifth class Dixon-based 4-class map. series rabbit dual-tracer exams, well subsequent human carotid studies, suggested maximum FDG:NaF ratio 4:1. This synthesis yielded sufficient signal robust segmentation major tissues, while FDG count statistics remained high. Finally, average 15% improvement was observed quantification 5-tissue correction method.

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