Scaleup of wet granulation processes: science not art

摘要: Significant advances have been made in the last decade to quantify process of wet granulation. The attributes product granules from granulation are controlled by a combination three groups processes occurring granulator: (1) wetting and nucleation, (2) growth consolidation (3) breakage attrition. For first two these processes, key controlling dimensionless defined regime maps presented validated with data tumbling mixer granulators. Granulation is an example particle design. quantitative analysis, both careful characterisation feed formulation knowledge operating parameters required. A thesis this paper that design, scaleup operation can now be considered as engineering rather than black art. Resume