作者: Morsy A. M. Abu-Youssef , Vratislav Langer , Lars Öhrström
DOI: 10.1039/B516723J
关键词: Molecule 、 Medicinal chemistry 、 Escherichia coli 、 Antimicrobial 、 Chemistry 、 Crystal structure 、 Stereochemistry 、 Quinoxaline 、 Isostructural 、 Coordination polymer 、 Group 2 organometallic chemistry
摘要: The synthesis and low temperature crystal structures of [Ag(quinoxaline)]n(NO3)n, 1, [Ag(2,5-dimethylpyrazine)(NO3)]n, 2 [Ag4(3-aminopyridine)4(NO3)4]n3 are presented. quinoxaline compound forms a 1D coordination polymer with the characteristic linear 2-coordination figure silver(I), N–Ag–N angle being 164.2(1)°, only weak silver–nitrate interactions. In addition there is an interaction giving pairs parallel chains as main structural theme. 2,5-dimethylpyrazine has approximately trigonal-planar coordination, also binding one nitrate at relatively short Ag–O distances 2.444(3) A 2.484(3) A, respectively, for two crystallographically different silver atoms. This results in that, despite large differences Ag(I) environment, isostructural 1. 2D by bridging ions. antimicrobial activity 1–3, [Ag3(2-aminopyridine)4](NO3)3, 4 was screened 13 pathogens substantial shown 1 against Escherichia coli Pseudomonas aeruginosa (MIC µg cm−3) somewhat lower registered Sarcina lutea Salmonella typhi Bordetella bronchiseptica 2, 3, Shigella sonnie 3 8 cm−3). Only yeast Candida albicans whereas no this pathogen 3.