Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: protective effects of vitamin E, vitamin C, and carnitine.
作者： S. Asha Devi , R. Vani , M. V. V. Subramanyam , Shiva Shankar Reddy , K. Jeevaratnam
DOI: 10.1002/CBF.1344
关键词: Chemistry 、 Malondialdehyde 、 Lipid peroxidation 、 Vitamin E 、 Biochemistry 、 Antioxidant 、 Endocrinology 、 Erythrocyte fragility 、 Vitamin C 、 Protein oxidation 、 Internal medicine 、 Carnitine
摘要: This study was aimed at determining the effect of vitamin E, C, and carnitine on intermittent hypobaric-hypoxia-induced oxidative stress (OS) in erythrocytes. For this purpose, male Wistar rats 4 months age were orally supplemented with one antioxidants prior to exposure altitudes 5700 m or 6300 m. Hemoglobin (Hb) OS indices such as osmotic fragility hemolysis measured together lipid peroxidation (LPO) protein oxidation. The increase Hb accompanied by activities antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) during both without any further elevation supplements. extent reduction E greater than Increase LPO products, for example, malondialdehyde (MDA) lipofuscin-like autofluorescent substances (AFS) noticeable altitudes, effective reducing LPO. While oxidation products carbonyl content (PrC) advanced (AOPP) increased m, sulphydryl (P-SH) decreased. P-SH levels restored supplementation antioxidants. Hence, our results indicate that may be beneficial overcoming under situations hypobaric hypoxia (IHH) hypobarotherapy wherein is used correct many pathological humans. Further, suggests L-carnitine alone not combination can attenuating associated IHH compared unsupplemented exposed two different altitudes. Copyright © 2006 John Wiley & Sons, Ltd.
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