Viscous dietary fiber reduces adiposity and plasma leptin and increases muscle expression of fat oxidation genes in rats

摘要: Dietary interventions that reduce accumulation of body fat are great interest. Consumption viscous dietary fibers cause well-known positive metabolic effects, such as reductions in the postprandial glucose and insulin concentrations. However, their effect on composition fuel utilization has not been previously studied. To examine this, rats were fed a nonfermentable fiber, hydroxypropyl methylcellulose (HPMC), for 6 weeks. Body was measured by dual-energy X-ray absorptiometry (DXA) pad weight. Plasma adipokines, AMP kinase activation, enzyme mRNA analysis key regulators energetics liver soleus muscle measured. The HPMC diet significantly lowered percent mass increased lean mass, compared to cellulose-containing (no viscosity). Fasting leptin reduced 42% resistin 28% group cellulose group. Rats had greater activation lower phosphoenolpyruvate carboxykinase (PEPCK) expression liver. skeletal carnitine palmitoyltransferase 1B (CPT-1B), PPARγ coactivator 1α, PPARδ uncoupling protein 3 (UCP3), citrate synthase (CS) activity, relative These results indicate fiber preserves reduces adiposity, possibly increasing mitochondrial biogenesis fatty acid oxidation muscle, thus represents described. Thus, may be useful component assist reduction fat.