Rapid formation and remodeling of postsynaptic densities in developing dendrites.
作者： Glen S. Marrs , Steven H. Green , Michael E. Dailey
DOI: 10.1038/NN717
关键词: Postsynaptic potential 、 Postsynaptic density 、 Spine (zoology) 、 Dendrite 、 Neuroscience 、 Hippocampal formation 、 Biology 、 Direct Extension
摘要: The dynamics of postsynaptic density (PSD) formation and remodeling were investigated in live developing hippocampal tissue slices. Time lapse imaging transfected neurons expressing GFP-tagged PSD95, a prominent PSD protein, revealed that up to 40% PSDs dendrites are structurally dynamic; they rapidly (<15 min) appear or disappear, but also grow, shrink move within shafts spines. New spines containing formed by conversion dynamic filopodia-like spine precursors which appeared de novo, direct extension carrying preformed from the shaft. therefore highly structures can undergo rapid structural alteration dendrite shafts, precursors, permitting synaptic connections CNS tissues.
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