Paradigms lost-an emerging role for over-expression of tight junction adhesion proteins in cancer pathogenesis.

摘要: Tight junctions (TJ) are multi-protein complexes located at the apicalmost tip of lateral membrane in polarised epithelial and endothelial cells. Their principal function is mediating intercellular adhesion polarity. Accordingly, it has long been a paradigm that loss TJ proteins consequent deficits cell-cell required for tumour cell dissemination early stages invasive/metastatic cascade. However becoming increasingly apparent play important roles not just but also intracellular signalling events, activation which can contribute to, or even drive, progression metastasis. In this review, we shall therefore highlight cases wherein gain associated with signals promoting progression. We will discuss potential overexpressed to act as therapeutic targets cancer treatment. The overall purpose review disprove fact TJ-based contributes several cancers, rather introduce growing body evidence may have adhesion-independent consequences other cancers.