Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells
作者： Chung-Pu Wu , Megumi Murakami , Sung-Han Hsiao , An-Wei Chou , Yan-Qing Li
DOI: 10.1021/ACS.MOLPHARMACEUT.7B00277
关键词: RPTOR 、 Kinase activity 、 Cancer cell 、 PI3K/AKT/mTOR pathway 、 Biology 、 Cell biology 、 Protein kinase B 、 Abcg2 、 ATP-binding cassette transporter 、 Cancer
摘要: Deregulated activation of phosphoinositide 3-kinase (PI3K)/Akt/mammalian target rapamycin (mTOR) pathway is frequently found in human cancers, which plays a key role promoting cancer proliferation and resistance to anticancer therapies. Therefore, developing inhibitors targeting components the PI3K/Akt/mTOR signaling has great clinical significance. PF-4989216 novel, orally available small-molecule drug that was developed selectively inhibit subsequent cell proliferation. exhibited potent selective inhibition against PI3K kinase activity preclinical small-cell lung (SCLC) models, especially effective SCLCs harboring PIK3CA mutation. Unfortunately, addition innate mechanisms, extrusion by efflux pumps may also contribute development acquired cells. The overexpression ATP-binding cassette (ABC)...
acs.org
sci-hub.se 参考文章(67)
Kip A West, S Sianna Castillo, Phillip A Dennis, Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resistance Updates. ,vol. 5, pp. 234- 248 ,(2002) , 10.1016/S1368-7646(02)00120-6
Amit K. Tiwari, Kamlesh Sodani, Chun-ling Dai, Alaa H. Abuznait, Satyakam Singh, Zhi-Jie Xiao, Atish Patel, Tanaji T. Talele, Liwu Fu, Amal Kaddoumi, James M. Gallo, Zhe-Sheng Chen, Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Letters. ,vol. 328, pp. 307- 317 ,(2013) , 10.1016/J.CANLET.2012.10.001
Takeo Nakanishi, Ken Shiozawa, Bret A. Hassel, Douglas D. Ross, Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood. ,vol. 108, pp. 678- 684 ,(2006) , 10.1182/BLOOD-2005-10-4020
Carine Tang, Lisa Schafranek, Dale B. Watkins, Wendy T. Parker, Sarah Moore, Jodi A. Prime, Deborah L. White, Timothy P. Hughes, Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways Leukemia & Lymphoma. ,vol. 52, pp. 2139- 2147 ,(2011) , 10.3109/10428194.2011.591013
Juu-Chin Lu, Yu-Tzu Chang, Chih-Tien Wang, Yu-Chun Lin, Chun-Ken Lin, Zhong-Sheng Wu, None, Trichostatin A Modulates Thiazolidinedione-Mediated Suppression of Tumor Necrosis Factor α-Induced Lipolysis in 3T3-L1 Adipocytes PLoS ONE. ,vol. 8, pp. e71517- ,(2013) , 10.1371/JOURNAL.PONE.0071517
C Garcia-Echeverria, W R Sellers, Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. ,vol. 27, pp. 5511- 5526 ,(2008) , 10.1038/ONC.2008.246
Chun-ling Dai, Amit K Tiwari, Chung-Pu Wu, Xiao-dong Su, Si-Rong Wang, Dong-geng Liu, Charles R Ashby Jr, Yan Huang, Robert W Robey, Yong-ju Liang, Li-ming Chen, Cheng-Jun Shi, Suresh V Ambudkar, Zhe-Sheng Chen, Li-wu Fu, None, Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2 Cancer Research. ,vol. 68, pp. 7905- 7914 ,(2008) , 10.1158/0008-5472.CAN-08-0499
Robert W. Robey, Tomasz Obrzut, Suneet Shukla, Orsolya Polgar, Sira Macalou, Julian C. Bahr, Attilio Di Pietro, Suresh V. Ambudkar, Susan E. Bates, Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemotherapy and Pharmacology. ,vol. 64, pp. 575- 583 ,(2009) , 10.1007/S00280-008-0908-2
Jurjen S. Lagas, Robert A.B. van Waterschoot, Vicky A.C.J. van Tilburg, Michel J. Hillebrand, Nienke Lankheet, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel, Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment Clinical Cancer Research. ,vol. 15, pp. 2344- 2351 ,(2009) , 10.1158/1078-0432.CCR-08-2253
Marlena Walls, Sangita M. Baxi, Pramod P. Mehta, Kevin K.-C. Liu, JinJiang Zhu, Heather Estrella, Chunze Li, Michael Zientek, Qing Zong, Tod Smeal, Min-Jean Yin, Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216 Clinical Cancer Research. ,vol. 20, pp. 631- 643 ,(2014) , 10.1158/1078-0432.CCR-13-1663