Acylation of salicylamide to 5-acetylsalicylamide using ionic liquids as dual catalyst and solvent
作者： Weiguang Chen , Hengbo Yin , Yunsheng Zhang , Zhangzhun Lu , Aili Wang
DOI: 10.1016/J.JIEC.2010.05.009
关键词: Friedel–Crafts reaction 、 Solvent 、 Nitrobenzene 、 Catalysis 、 Salicylamide 、 Ionic liquid 、 Chemistry 、 Acylation 、 Organic chemistry 、 Acetyl chloride
摘要: The Lewis acidic ionic liquids, 1-butyl-3-methylimidazolium chloroaluminate ([BMIM]Cl-nAlCl3) and N-butylpyridinium ([BPy]Cl-nAlCl3), were used as both catalyst solvent in Friedel–Crafts acylation of salicylamide with acetyl chloride to 5-acetylsalicylamide. substituting for the conventional carcinogenic nitrobenzene anhydrous AlCl3 catalyst, showed excellent catalytic activity When [BMIM]Cl-2AlCl3 was yield 5-acetylsalicylamide reached 81.3%. [BPy]-2AlCl3 maximum 89.2%. content structure cations liquids had synergistic effect on reaction.
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