Caffeoylquinic acids competitively inhibit pancreatic lipase through binding to the catalytic triad.
作者： Bing Hu , Fengchao Cui , Fangping Yin , Xiaoxiong Zeng , Yi Sun
DOI: 10.1016/J.IJBIOMAC.2015.07.031
关键词: Hydrogen bond 、 Chlorogenic acid 、 Stereochemistry 、 Triacylglycerol lipase 、 Catalytic triad 、 Docking (molecular) 、 Caffeoylquinic acid 、 Chemistry 、 Lipase 、 Hydrophobic effect
摘要: Caffeoylquinic acid and its isomers inhibited porcine Pancreatic Lipase (PL) activity according to a competitive mode where binding and interaction with the catalytic triad of Ser153, His264 and Asp177 simultaneously occurred. The IC 50 values under which 3-caffeoylquinic acid (CQA) and its isomers 4-, 5-CQA, 3, 4-, 3, 5-and 4, 5-diCQA inhibited half of the porcine PL activity were 1.10, 1.23, 1.24, 0.252, 0.591 and 0.502 mM, respectively. The binding affinities in the range from− 8.4 to− 9.5 kCal/mol were well predicted from …
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