Characterization of PAHs in size-fractionated submicron atmospheric particles and their association with the intracellular oxidative stress
作者： Qinghua Zhou , Baichen Liu , Yimei Chen , Xiaoqian Han , Xiuzhen Wei
DOI: 10.1016/J.CHEMOSPHERE.2017.04.133
关键词: Size fractionated 、 Intracellular 、 A549 cell 、 Glutathione 、 Carcinogen 、 Particulates 、 Oxidative stress 、 Chemistry 、 Environmental chemistry
摘要: The submicron atmospheric particulate matters (PMs), consisting of 7 size-resolved fractions, were collected by two Dekati low pressure impactors from December 2015 to January 2016 in Hangzhou, China. chemical analysis revealed the higher accumulation efficiency polycyclic aromatic hydrocarbons (PAHs) finer PMs, and 77.0% PAHs PM1 associated with PM0.4. Moreover, BaP equivalent concentrations (BaPeq) evaluated for size-fractionated indicating that 77.2% carcinogenicity In cytotoxic tests, a significant size-dependent decrease glutathione (GSH) level was observed PMs-exposed human pulmonary epithelial cells (A549), demonstrating greater intracellular oxidative stress induced PMs. results also suggested 82.4% PM1-induced PM0.4, significantly correlated PAHs. Therefore, besides PM10, PM2.5 PM1, special attentions should be given PM0.4 as well.
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